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White 99 is my choice for combating Multiple Sclerosis extreme fatigue. Consuming sugar and caffeine to overcome fatigue only helped with mental alertness. I would still have to constantly "mentally force" myself to get up, move and accomplish with the heavy feeling that all movement was a weighted down chore of effort .. ..always mentally prodding myself to keep going. Along the way fatigue wins and must stop, with the alertness continuing thoughts of disappointment/ despair being defeated again. With 2 to 3 hits of White 99 in 10 minutes, the heavy fatigue cloud lifts, replaced with uplifting feelings of inspiration to accomplish. The heavy body burden is replaced with a wave of mental and physical energy which makes doing things simple and easy as they should be. Warning: The best fatigue benefit only happens when taking a small amount, because when consuming more this strain will mentally uplift and inspire multiple things, where I start to spin in circles multitasking leaving remnants of tasks everywhere. Is is a great product to zone out with pleasant joyful thoughts in the early evening. Late night may be a problem because you don't want the party to end from all the mental stimulation .