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I'm a 73 yr. old man. I've had 30 plus years of severe arthritis (including both knees and a hip replaced, and regular Cortizone shots up and down my spine)) and debilitating joint pain and inflammation etc. etc.. I've used Cookies and Chem now for aprox. 18 months. It gives me 2-4 hrs. of near complete pain relief. It has also really helped reduce the inflammation in my joints, to the point I can work and exercise again after nearly 20 years. It has been a life-saver for me.